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D-dimers emerge during fibrinolysis as a degradation product of fibrin. The circulating enzyme plasmin cleaves the fibrin gel in a number of places, in order to prevent blood clots from accumulating to a problematic size. However the cross-link between two D fragments remains intact. The structure of D-dimer is either a 180 kDa or 195 kDa molecule of two D domains, or a 340 kDa molecule of two D domains combined with one E domain of the original fibrinogen molecule.
In clinical diagnostic the D-dimer concentration is an indicator for thrombosis. D-dimer is relevant to research into thrombosis, with common target including fibrinogen, fibrin degradation product, plasminogen activity.
Stability: The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5 % within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.
Recommended dilutions: Optimal dilutions/concentrations should be determined by the end user.
Standard Form: Lyophilized