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anti-Immunoglobulin D (IgD) Secondary Antibodies

Written/Edited by Julian Pampel, BSc

IgD (IgD) is a monomeric antibody isotype that is expressed in the plasma membranes of immature B-lymphocytes. IgD is also produced in a secreted form that is found in small amounts in blood serum. Secreted IgD is made up of two heavy chains of the delta class, and two light chains. IgD's function has long been a conundrum and is still incompletely understood. IgD is present in species ranging from fish to human (probably with the exception of birds), indicating that IgD has been preserved since its ancient origins which suggests that IgD has important immunological functions.

It is known that IgD signals for B cells to be activated in order for them to participate in the immune defence. Apparently IgM and IgD share this role, with IgM being expressed sooner in the life-cycle of B-cells than IgD. It is not well understood what the functional difference of IgM and IgD on B cells is. Knock-out mice models have not yielded any major intrinsic defects. In fact, heavy chains of IgM and IgD are encoded by a common transcription unit. IgM-/- mice show normal B-cell development and maturation, with IgD replacing membrane-bound and secretory IgM. These data suggest that IgD is largely able to substitute for IgM functions in B-cells. IgD apparently is also able to bind to basophils and mast cells and activate these cells to produce antimicrobial factors that are functional in respiratory immune defence in humans.
Immunoglobulin D (IgD)

IgD Secondary Antibodies

Product
Clonality
Application
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Application FACS, IHC (fro)
Cat. No. ABIN2749203
Validations
  • (6)
  • (2)
Quantity 0.1 mg
Datasheet Datasheet
Clonality Monoclonal
Application FACS
Cat. No. ABIN6240825
Validations
  • (3)
Quantity 100 tests
Datasheet Datasheet
Clonality Monoclonal
Application FACS
Cat. No. ABIN135030
Validations
  • (1)
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Monoclonal
Application FACS
Cat. No. ABIN135032
Validations
  • (1)
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Polyclonal
Application FACS, ELISA
Cat. No. ABIN376508
Validations
  • (5)
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Monoclonal
Application FACS
Cat. No. ABIN135031
Validations
  • (1)
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Monoclonal
Application FACS
Cat. No. ABIN2749204
Validations
  • (6)
  • (1)
Quantity 100 tests
Datasheet Datasheet
Clonality Polyclonal
Application FACS, ELISA, WB
Cat. No. ABIN376896
Validations
  • (1)
Quantity 1 mg
Datasheet Datasheet

Featured IgD Antibodies conjugated to Alexa Fluor 700

Featured IgD Antibodies conjugated to Alexa Fluor 647

Featured IgD Antibodies conjugated to Alexa Fluor 488

Featured IgD Antibodies conjugated to FITC

Product
Clonality
Application
Cat. No.
Validations
Quantity
Datasheet
Clonality Monoclonal
Application FACS
Cat. No. ABIN135031
Validations
  • (1)
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Polyclonal
Application FACS, ELISA
Cat. No. ABIN376130
Validations
  • (1)
Quantity 1 mg
Datasheet Datasheet
Clonality Polyclonal
Application FACS, ELISA
Cat. No. ABIN376131
Validations
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Monoclonal
Application FACS, ELISA
Cat. No. ABIN376205
Validations
  • (1)
Quantity 0.5 mg
Datasheet Datasheet
Clonality Polyclonal
Application ELISA, IF, IHC (fro), ICC
Cat. No. ABIN458020
Validations
Quantity 1 mL
Datasheet Datasheet
Clonality Polyclonal
Application ELISA, IF, IHC (fro), ICC
Cat. No. ABIN458171
Validations
Quantity 1 mL
Datasheet Datasheet
Clonality Polyclonal
Application ELISA, IF, IHC (fro), ICC
Cat. No. ABIN458493
Validations
Quantity 1 mL
Datasheet Datasheet
Clonality Polyclonal
Application ELISA, IF, IHC (fro), ICC
Cat. No. ABIN458377
Validations
Quantity 1 mL
Datasheet Datasheet

What is IgD?

IgD (IgD) is a monomeric antibody isotype that is expressed in the plasma membranes of immature B-lymphocytes. IgD is also produced in a secreted form that is found in small amounts in blood serum. Secreted IgD is made up of two heavy chains of the delta class, and two light chains.

What is the function of IgD?

IgD's function has long been a conundrum and is still incompletely understood. IgD is present in species ranging from fish to human (probably with the exception of birds), indicating that IgD has been preserved since its ancient origins which suggests that IgD has important immunological functions. It is known that IgD signals for B cells to be activated in order for them to participate in the immune defence. Apparently IgM and IgD share this role, with IgM being expressed sooner in the life-cycle of B-cells than IgD.

Learn more about other secondary antibody types

Julian Pampel
Julian Pampel, BSc
Content Manager at antibodies-online.com

Creative mind of antibodies-online with a keen eye for details. Proficient in the field of life-science with a passion for plant biotechnology and clinical study design. Responsible for illustrated and written content at antibodies-online as well as supervision of the antibodies-online scholarship program.

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