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Canonical PathwayActive
WNT SIGNALING
Non-Canonical PathwayWNT/Ca2+
Non-Canonical PathwayWNT/PCP
Canonical PathwayInactive
TCF/LEF
Nucleus
HDAC
Groucho
CK1 ε
β-catenin
AXIN1
APC
YAP/TAZ
CK1 δ
CK1 α
βTrCP
FBXW7
Wtx
NEDDL4
P
UB
Degration by Proteasome
GSK3β
P
P
P
UB
E-Cadherin
LRP5/6
Frizzled
RNF43
LGR5
α-catenin
β-catenin
UB
DVL
UB
UB
YAP/TAZ
LRP5/6
Frizzled
RNF43
LGR5
DVL
P
DVL
P
CDK14
WNT
WNT
WNT
P
βTrCP
β-catenin
P
P
P
P
PYGO
BRG1
TBP
TCF
BCL9
CBP
β-catenin
Rspondin2
CK1 ε
DVL
DVL
WNT
Frizzled
RYK
VANGL
CDC42
JNK
RAC1
RHOA
DAAM1
PK
P
DVL
P
P
ROCK
WNT
Frizzled
RYK
WNT
DVL
PLC
Calcineurin
PKC
Calpain-1
NFAT
CDC42
CamKIV
Ca2+
DAG
IP3
IP3
IP3
DAG
DAG
GSK3β
Ca2+
Ca2+
Ca2+
Ca2+
June
ATF2
NFAT
NF-κB
NFAT
NF-κB
Destruction Complex
P
P
P
CK1 α
GSK3β
AXIN1
APC
Destruction Complex
CK1 α
P
G-Protein
Rspondin2
Ubiquination Complex